Hua Liang, MD & PhD
Titles
Associate Professor of Physician
Vice Director, Division of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-sen University
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Research Interests
·Monogenetic Diabetes
·Lipid metabolism
Her research interest is in monogenic diabetes, a rare type of diabetes due to single gene mutations or chromosomal abnormalities, representing ~1-5% of all diabetes cases, especially ?focusing on the maturity-onset diabetes of the young (MODY), neonatal diabetes mellitus (PDM), and several insulin resistance syndromes. She has reported so far the first Chinese MODY2 pedigree caused by GCK gene mutation, and a rare case of severe insulin resistance syndrome with LMNA C deficiency. Additionally, she also has great interest in Lipid metabolism especially the molecular mechanism by which PNPLA3 confers susceptibility to liver injury and hepatic fat accumulation.
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Education and Experience
Education
·Kanazawa University, Japan – Diabetes ?Ph.D. (04/2001 - 03/2005)
·Guangxi Medical University, China – Clinical Medicine ?B.S. (09/1994 - 06/1999)
Working and Training
·Department of Endocrinology and Metabolism, 3rd Affiliated Hospital of SYSUMS, Canton, China – Associate Professor (01/2010 – present)
·Department of Endocrinology and Metabolism, 3rd Affiliated Hospital of SYSUMS, Canton, China – Senior physician (12/2007 – 12/2009)
·Postdoctoral research station of clinical medicine, Sun Yat-sen University of Medical Science(SYSUMS), Canton, China – Postdoc (8/2005 - 11/2007)
·The 1st hospital of Guangxi Medical University, China – House physician (7/1999-6/2000)
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Honor and Award
The Chinese Journal of Diabetes Outstanding Paper Award, 2011
Publications
1.Liang H, Xu J, Xu F, Liu H, Yuan D, Yuan S, Cai M, Yan J, Weng J. The SRE Motif in the Human PNPLA3 Promoter (-97 to -88?bp) Mediates Transactivational Effects of SREBP-1c. Journal of Cellular Physiology, 2015 ?Sep;230(9):2224-32. (IF3.839)
2.Bi Y, Wu W, Shi J,?Liang H, Yin W, Chen Y, Tang S, Cao S, Cai M, Shen S, Gao Q, Weng J, Zhu D. Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription. Diabetologia. 2014, 57(3):592-602. (Co-first author)(IF:6.671)
3.Hua Liang, Mengyin Cai, Yan Bi, Yanhua Zhu, Jinhua Yan, Jianping Weng. A single nucleotide polymorphism (SNP) rs2072907 in the adiponutrin gene (ADPN) was not associated with obesity and type 2 diabetes in Chinese population. Diabetes Res Clin Pract. 2009, 85(3):e37-e39. (IF 2.538)
4.Yan Bi, Mengyin Cai, Hua Liang, Weiping Sun, Xiubin Li, Chunxia Wang, Yanhua Zhu, Xiang Chen, Ming Li, Jianping Weng Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element–binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat–diet and streptozotocin-induced diabetic rats. Metabolism, 2009, 58(6):779-786. (Co-first author) (IF:3.894)
5.Liang H, Murase Y, Katuta Y, Asano A, Kobayashi J, Mabuchi H. LMNA 1908C/T polymorphism with Cerebral Vascular Disease and Diabetic Nepheropathy in Japanese men with type 2 diabetes. Clin Endocrinol (Oxf). 2005, 63(3):317-322. (IF:3.457)
6.Hua Liang, Kunimasa Yagi, Akimichi Asano, Junji koizumi, Hiroshi Mabuchi. Association between CTLA-4 +49A/G polymorphism and type 1B diabetes in Japanese population Endocrine 2004, 25 (2): 105-109. (IF: 3.878)
7.Shen Y, Cai M, Liang H,?Wang H, Weng J*. Insight into the biochemical characteristics of a novel glucokinase gene mutation. Hum Genet, 2011 ,129(3):231-8. (IF: 4.824)
8.Sun W, Bi Y, Liang H, Cai M, Chen X, Zhu Y, Li M, Xu F, Yu Q, He X, Ye J, Weng J. Inhibition of obesity-induced hepatic ER stress by early insulin therapy in obese diabetic rats. Endocrine,2011,39(3):235-41. (IF: 3.878)
9.CAI Meng-yin,?LIANG Hua, LI Ming, BI Yan, CHEN Xiang, SUN Wei-ping and WENG Jian-ping. Lamin C protein deficiency in the primary fibroblasts from a new laminopathy case with ovarian cystadenoma. Chinese Medical Journal 2010;123(16):2237-2243. (IF 1.053)
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Contact
The Third Affiliated Hospital of Sun Yat-sen University
600 N. Tianhe Road
Scientific Building, 1702
Guangzhou, 510630
Appointment Phone:?86-20-85252073
