Yubao Zheng, PhD,MD

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Titles

Associate Professor of hepatology.

Master's Supervisor

Department of Infectious Diseases, The Third Affiliated Hospital of SunYat-Sen University

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Educations and Experiences

1994-1999 Clinical Medicine, AnHui Medical University, Feihe, AnHui Province

2002-2005 Master of Medicine, BengBu Medical College, BengBu, AnHui Province

2006-2009 M.D, Ph.D (hepatology), Sun Yat-sen University, The Third Affiliated Hospital, Guangzhou , Guangdong province

2005-2006 Lecturer of Medicine, Beng Bu Medical College, BengBu, AnHui Province

2009-2012 Lecturer of Medicine, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou Guangdong province

2013-To now Associate Professor of Hepatology, Sun Yat-sen University, Zhongshan School of Medicine, Guangzhou, Guangdong province

1999-2002 Resident, the First Affiliated Hospital of Beng Bu Medical College, BengBu, AnHui Province

2005-2006 Attending Physician, the First Affiliated Hospital of Beng Bu Medical College, BengBu, AnHui Province

2009-2012 Attending Physician, Department of Infectious Diseases(Liver Center), the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong province

2013 to now Associate Chief Physician, Department of Infectious Diseases(Liver Center), the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong province

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Research Interest

My research focuses on estimating the severity of acute-on-chronic liver failure in hepatitis B, treatment of acute-on-chronic liver failure with hepatitis B and exploration of the mechanism of acute-on-chronic HBV liver failure.

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Below is my current research topic in detail:

(1) Acute-on-chronic Liver Failure, especially on liver failure with hepatitis B and Prognostic assessment of patients with acute-on-chronic liver failure in hepatitis B; We developed a novel prognostic scoring system, calculated from six clinical indices including serum total bilirubin, prothrombin activity, serum creatinine, hepatic encephalopathy, infections, Thickness of RLL and the depth of ascites(Clin Inest Med 2012; 35 (2): E75-E85, Hepatol Int 2012; 6:727–734).

(2) Stem cells for the treatment of acute chronic liver failure research, we found that Amniotic-Fluid–

Derived Mesenchymal Stem Cells Overexpressing Interleukin-1 Receptor Antagonist Improve

Fulminant Hepatic Failure and Autologous bone marrow mesenchymal stem cell transplantation in

liver failure patients caused

by hepatitis B: short-term and long-term outcomes.(Hepatology. 2011, 54(3):820-8. (2012) PLoS ONE 7

(7): e41392)

3) The mechanism of Acute-on-chronic Liver Failure; end-stage liver Disease including Liver cirrhosis such as Viral hepatitis, Alcoholic liver disease and Autoimmune liver cirrhosis; As far as I am concerned , I think that Liver failure process may be undergo three fatal blow including immune damage, hypoxia ischemia and endotoxemia in turn.

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Research Support (chronological)

2009-2012 The National Natural Science Foundation of China (project batch number: 30971356, the second major participant).

2010-2012 The Natural Science Foundation of Guangdong Province (Dr. Start-up projects), (project number: 10451008901004818, project leader)

2012-2015 Guangdong Province Natural Science Fund Project (project number: S2012010009084, project leader).

2013-2015 The National Natural Science Fund Project (the project batch number: 81202319, the second major participant)

2015-2018 The Science and Technology Program of Guangdong Province (the project number: 10451008901504588, project leader)

2016-2018 The Science and Technology Program of Guangzhou City (the project number: 201504301341501, project leader).

2016-2019 The Science and Technology Program of Guangdong Province (the project number: XXXXX, project leader).

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Awards and Honors

Scholarship

1997 General Honors, presented by AnHui Medical University

Sun Yat-sen University Awards

2008 Excellent Graduate Student, presented by the Sun Yat-sen University

2010 Distinguished Faculty Award, presented by the Third Affiliated Hospital of the Sun Yat-sen University

2011 Excellence in Teaching in Clinical Medicine, presented by the Sun Yat-sen University

2012 Excellence in Teaching in Clinical Skills of Hepatology, presented by the Third Affiliated Hospital of Sun Yat-Sen University.

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Editorial Boards and Activity

2009-To now: Reviewer for those Journals including The World Journal of Gastroenterology (WJG), BMJ Open, Journal Ttropical Medicine and The Journal of The Chinese Liver Disease such as referees.

2011-To now: Contributing Editor for Chinese journal of Clinical Physicians.

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Publications

1.Yu-Bao Zheng, Xiao-Hong Zhang, Zhan-Lian Huang, Chao-Shuan Lin, Zhi-Liang Gao etal. Amniotic-Fluid–Derived Mesenchymal Stem Cells Overexpressing Interleukin-1 Receptor Antagonist Improve Fulminant Hepatic Failure. (2012) PLoS ONE 7(7): e41392.

2.Yu-Bao Zheng(corresponding author), Shi-Bin Xie, Dong-Ying Xie, Liang Peng, Chao-Shuang Lin, Zhi-Xin Zhao, Zhi-Liang Gao et al. A Novel prognostic scoring system to predict 3-month mortality risk in patients with acute-on-chronic liver failure in hepatitis B: a retrospective cohort study. Hepatol Int 2012; 6:727–734.

3.Yu-Bao Zheng, Dong-Ying Xie, Yu-Rong, Ying Yan, Ze-Bin Wu, Zi-Ying Lei, Liang Peng, Zhi-liang Gao,Wei-min Ke. Development of a sensitive prognostic scoring system for the evaluation of severity of acute-on-chronic hepatitis B liver failure: A retrospective cohort study. Clin Inest Med 2012; 35 (2): E75-E85.

4.Yu-Bao Zheng, ZhiLiang Gao, Chan Xie, HaiPeng Zhu, Liang Peng, Chong YuTian. Characterization and hepatogenic differentiation of mesenchymal stem cells from human amniotic fluid and human bone marrow: a comparative study.Cell Biol Int. 2008 Nov;32(11):1439-48.

5.Yu-Bao Zheng, ZhiLiang Gao, Fei Zhong, YangShu Huang, Liang Peng, BingLiang Lin, Chong YuTian. Predictive value of serum-soluble CD154 in fulminant hepatic failure.. J Int Med Res. 2008 Jul-Aug;36(4):728-33.

6.Yu-Bao Zheng, Zhan Lian Huang, Zhe Bin Wu1, Min Zhang, Yu Rong Gu, Yu Jie Su, Chao Shuang Lin, Rui Hua Zhu, Bin Liang Lin, Zhi Liang Gao. Dynamic Changes of Clinical Features that Predict the Prognosis of Acute-on-Chronic Hepatitis B Liver Failure: A Retrospective Cohort Study. International Journal of Medical Sciences.2013; 10(12):1658-1664.

7 Chan Xie, Yu-Bao Zheng. Human Bone Marrow Mesenchymal Stem Cells are resistant to HBV Infection during differentiation towards Hepatocytes in vivo and vitro. Cell Biol Int. 2009, 24-27.

8. Liang Peng, Dongying Xie, Binliang Lin, Jing Liu, Haipeng Zhu, Chan Xie, Yubao Zheng, Zhiliang Gao. Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes. Hepatology. 2011;54(3):820-8.

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Academic Communication

2009, 2011 and 2012, American Association for the Study of Liver Diseases (AASLD) and

European annual liver (EASL) communication.

2012 Peking Ditan International Conference on Infectious Diseases, 6th DICID.

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Contact

Department of Infectious Diseases,

The Third Affiliated Hospital of Sun Yat-Sen University

No.600 Tianhe Road, Guangzhou 510630, China

Telephone: +86-20-85252372; Fax: +86-20-85252250

Mobilephone: +86(0)13631361926;

Email: zhybao@mail.sysu.edu.cn; guangzhouzyb@126.com

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